金麗華教授,博士生導師,遺傳學科學科帶頭人
聯系電話:15046109867
E-mail:lhjin@nefu.edu.cn, lhjin2000@hotmail.com
地址:黑龍江省哈爾濱市香坊區和興路26号
伟德官网下app官方网站(新逸夫教學樓) 254房間
學習經曆
2000.03-2003.02 韓國翰林大學老化生命科學理學博士
1998.03-2000.02 韓國江原大學應用生物與技術理學碩士
1989.09-1993.06 延邊大學化學系學士
工作經曆
2009.07月-至今伟德官网下app官方网站遺傳學科教授博士生導師
2005.08-2009.06 韓國延世大學基因調解中心研究教授
2003.03-2005.07 韓國延世大學基因調解中心博士後
專業特長:
遺傳學、分子生物學、細胞生物學、生物化學
研究方向:
細胞與分子免疫、遺傳與發育、疾病發生的分子機制、中藥及次生代謝産物的藥理作用
研究領域:
1、細胞與分子免疫:從分子水平揭示重要基因在細胞免疫、體液免疫、腸道免疫中的功能及在體内的調控機理。
2、遺傳與發育:揭示功能基因對個體生長發育、衰老、疾病發生、腫瘤形成等的影響及其分子機制。
3、中藥藥理:中藥及次生代謝産物在天然免疫、腸道免疫、脂肪代謝、抗氧化、抗衰老、抗腫瘤等的功能及作用。
承擔教學:
遺傳學、遺傳與免疫、分子免疫、最新遺傳學進展
承擔的科研項目:
2022.01-2025.12 國家自然科學基金主持人
果蠅Rab1蛋白在造血幹細胞穩态維持中的作用機制
2018.01-2021.12 國家自然科學基金主持人
Rab5蛋白調控果蠅造血作用的分子機制
2016.03-2020.02 中央高校基本科研業務費專項資金項目主持人
創新團隊與重大項目培育資金
藥用植物藥理及生理生态适應性研究主持人
2016.07-2019.06 黑龍江省基金主持人
藥用植物對果蠅腸道免疫和胰島素代謝的調節作用
2014.01 - 2016.12 高等學校博士學科點專項科研基金主持人
2013.01 - 2016.12 國家自然科學基金主持人
2013.04 - 2016.03 中央高校基本科研業務費專項資金項目主持人
創新團隊與重大項目培育資金
2012.01 - 2014.12教育部留學回國人員科研啟動基金主持人
2011.01 - 2013.12 國家人事部留學人員科技活動項目擇優資助經費主持人
2011.01 - 2013.12國家自然科學基金主持人
2010.10 - 2013.10 中央高校基本科研業務費專項資金項目主持人
傑出青年科研人才基金項目
2010.01 - 2010.12 國家自然科學基金,主持人
2009.08 - 2011.12 伟德官网下app官方网站高層次引進人才科研啟動項目主持人
主要發表學術論文(*為通訊作者):
1. Shichao Yu†, Fangzhou Luo†, Yongyi Xu, Yan Zhang,Li Hua Jin*Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues.Frontiers in immunology. 2022, 13:905370.醫學2區, Top期刊, IF 8.78
2. Xue Lei, Ziqian Zhou, Sihong Wang,Li Hua Jin*The protective effect of safranal against intestinal tissue damage in Drosophila.Toxicology and Applied Pharmacology.2022, 439:115939.毒理學2區, IF4.16
3. Jiewei Wang, Qiang Liu, Yuan Gong,Li Hua Jin*. Anchor maintains gut homeostasis by restricting the JNK and Notch pathways in Drosophila.Journal of Insect Physiology. 2021, 134: 104309.農林科學2區, IF 2.60
4. Shichao Yu, Fangzhou Luo,Li Hua Jin*. Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.Elife. 2021, 10:e60870.生物學1區, Top期刊, IF 8.71
此項研究成果被新華社、中新網和央廣網等媒體報道https://baijiahao.baidu.com/s?id=1694810822594054388&wfr=spider&for=pc
5. Fangzhou Luo, Shichao Yu,Li Hua Jin*. The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of the Drosophila Lymph Gland.Frontiers in Cell and Developmental Biology. 2020, 8:382.生物學2區,
IF 6.08
6. Hong Zhang, Sihong Wang,Li Hua Jin*. A canthopanax senticosus polysaccharide regulates the proliferation and differentiation of Drosophila intestinal stem cells. Phytotherapy Research. 2020,34:193-200.醫學2區, IF 6.39
7. Xiaochun Wang, Ziguang Liu,Li Hua Jin*. Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development.Apoptosis. 2019, 24:465-477.生物2區, IF 5.56
8. Yangguang Hao, Shichao Yu, Fangzhou Luo,Li Hua Jin*. Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.Cell Communication and Signaling. 2018, 5;16:95.生物2區, IF7.52
9. Xiao Chun Wang, Ziguang Liu ,Li Hua Jin*. Anchor negatively regulates BMP signalling to control Drosophila wing development.European Journal of Cell Biology. 2018, 97:308-317.生物3區, IF 6.0
10. Shichao Yu, Gaoqun Zhang,Li Hua Jin*. A high-sugar diet affects cellular and humoral immune responses in Drosophila.Experimental cell research. 2018, 15;368:215-224.醫學3區, IF 4.1
11. Shichao Yu, Fangzhou Luo,Li Hua Jin*.The Drosophila lymph gland is an ideal model for studying hematopoiesis.Developmental and Comparative Immunology. 2018, 83:60-69.生物2區, Top期刊, IF 3.6
12. Qiang Liu andLi Hua Jin*. The zinc finger protein CG12744 is essential for differentiation and regeneration after infection in the adult Drosophila midgut.Experimental Cell Research. 2017, 361:225-235.醫學3區, IF 4.1
13. Qiang Liu andLi Hua Jin*.Tissue-resident stem cell activity: a view from the adultDrosophilagastrointestinal tract.Cell Communication and Signaling. 2017, 18;15:33.生物2區, IF 7.52
14. Qiang Liu andLi Hua Jin*. Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective.Frontiers in Cell and Developmental Biology. 2017,3;5:29.生物2區, IF 6.1
15. Xiaoyue Zhang, Qiuxia Jin,Li Hua Jin*.High sugar diet disrupts gut homeostasis though JNK and STAT pathways in Drosophila.Biochemical and Biophysical Research Communications. 2017, 487: 910-916.生物3區, IF 3.3
16.Yangguang Hao,Li Hua Jin*.Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland.eLife. 2017;6:e25094.生物1區, Top期刊, IF 8.71
17. Gaoqun Zhang, Yangguang Hao,Li Hua Jin*. Overexpression of jumu induces melanotic nodules by activating Toll signaling in Drosophila.Insect Biochemistry and Molecular Biology. 2016,77:31-38.農林科學1區, Top期刊,IF 4.4
18.Jichuan Pan,Li Hua Jin*. rgn gene is required for gut cell homeostasis after ingestion of sodium dodecyl sulfate inDrosophila.Gene.2014,549:141-148.生物3區, IF 3.9
19.Caixia Zhu, Fachun Guan, Chao Wang,Li Hua Jin*.The Protective Effects of Rhodiola crenulata Extracts onDrosophila melanogasterGut Immunity Induced by Bacteria and SDSToxicity.Phytotherapy Research. 2014,28:1861-1866.醫學2區, IF 6.39
20.Li Hua Jin, Jung Kyoon Choi, Byungil Kim,Hwan Sung Cho,Jihyun Kim,Jeongsil Kim-Ha, Young-Joon Kim*. Requirement of Split ends for Epigenetic Regulation of Notch Signal-Dependent Genes during Infection-Induced Hemocyte Differentiation.Molecular and Cellular Biology, 2009, 29:1515-1525.生物3區, IF 5.0
21.Li Hua Jin, Jaewon Shim, Joon Sun Yoon, Byungil Kim, Jihyun Kim, Jeongsil Kim-Ha, Young-Joon Kim*. Identification and Functional Analysis of Antifungal Immune Response Genes in Drosophila.PLoS Pathogens, 2008, 4:e1000168.
生物1區, Top期刊, IF7.46
授權發明專利:
1.金麗華;李娜.闆藍根提取物對果蠅殺蟲作用的應用.
專利号:201811463244.8
2.金麗華;于世超;柳宗琳. 藏紅花在緩解果蠅腸道炎症損傷中的應用.
專利号:ZL201510623731.6
3.金麗華;于世超;王超.工布烏頭在緩解果蠅腸道炎症損傷中的應用.
專利号:201510377387.7
4.金麗華;周洋.瓜蒌、紅花和川穹在緩解果蠅腸道氧化應激損傷中的應用.
專利号:201410155605.8
5.金麗華;朱彩霞;關法春;蘭小中.西藏大花紅景天提取物在制備抗腸道炎症藥物中的應用.專利号:201310594361.9
6.金麗華,張玮钰,李文佳.刺五加水提取物在緩解果蠅腸道炎症中的應用.
專利号:ZL201210299779.2
獲獎:
1.中國林業青年科技獎(第十二屆林業青年科技獎)(國家林業局)2013年9月
木本藥用植物對免疫功能及胰島素代謝的影響
2.黑龍江省自然科學獎三等獎(黑龍江省科技廳),伟德官网下app官方网站金麗華,郝陽光,劉強,張高群,李文佳 2020年9月