李立新 教授,博士生導師
高層次引進人才。Molecular Plant、New Phytologist、Plant Physiology, BMC plant biology、《遺傳》、《植物生理學報》、《農業生物技術學報》、《中國草地學報》等雜志審稿專家.
電子郵箱:lixinli0515@nefu.edu.cn
地址:黑龍江省哈爾濱市香坊區和興路26号
伟德官网下app官方网站(新逸夫教學樓)
教育經曆
1987.09-1991.06學士 東北師範大學生物系 生物學專業
2003.04-2005.03理學碩士 日本京都大學大學院理學部 分子細胞生物學專業
2005.04-2008.03理學博士 日本京都大學大學院理學部 分子細胞生物學專業
工作經曆
2008.04-至今 伟德官网下app官方网站 伟德官网下app官方网站/東北鹽堿植被恢複與重建教育部重點實驗室 教授
2014.07-2016.05沙特國王科技大學 沙漠農業中心 訪問學者
2012.11-2013.10 馬裡蘭大學 農學院 訪問學者
2009.08-2012.07 沙特國王科技大學 逆境基因組研究中心 博士後
1991.07-2000.10 哈爾濱市第一中學教師
研究領域
1.逆境條件下植物發育和脅迫應答機制;2.逆境條件下植物與微生物互作機制
講授課程
本科生課程:《分子生物學》、《植物發育生物學》
研究生課程:《植物代謝與調控專題》
科研項目
(1)國家自然科學基金面上項目:鹽堿脅迫下膜泡運輸因子AtSYP71參與的細胞pH和離子穩态調控機制 (32170279),2022/01-2025/12,主持人。
(2)中央高校基本科研業務費專項資金創新團隊項目:囊泡運輸調控植物鹽堿脅迫應答分子機制的研究(2572019CT03),2019/05-2022/04,主持人。
(3)國家自然科學基金面上項目:拟南芥MAG2和同源蛋白MAL缺失對生長素極性運輸的影響(31570246),2016/01-2019/12,主持人。
(4)黑龍江省自然科學基金:儲藏蛋白質運輸相關AtSly1因子功能分析(C2016002),2016/01-2018/12,主持人。
(5)中央高校基本科研業務費專項資金創新團隊資助:膜泡運輸調控因子MIP2調控植物生長發育的機制初探(DL13EA04),2013.04-2016.03,主持人。
(6)國家自然科學基金面上項目:ER-SNARE在種子儲藏蛋白質轉運中的功能分析(30970223),2010/01-2013/12,主持人。
(7)中央高校基本科研業務費專項資金資助:膜泡運輸中新型因子初探(DL09DA02),2010/01-2012/12,主持人。
(8)國家自然科學基金主任基金:植物種子細胞中儲藏蛋白質轉運的相關因子AtUfe1的功能分析(30840002),2009/01-2009/12,主持人。
代表性及近期學術論文
Wang Xiaoting, Wang Mingyu, Huang Yongshun, Zhu Peng, Qian Guangtao, Zhang Yiming, Liu Yuqi, Zhou Jingwen andLi Lixin*.Genome-Wide Identification and Analysis of Stress Response of Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase Genes in Quinoa. 2023. Int. J. Mol. Sci. doi: 10.3390/ijms24086950.
Qian G., Li X., Zhang H., Zhang H., Zhou J., Ma X., Sun W., Yang W., He R., Wahab A., Wan H.,Li Lixin*Metabolomics analysis reveals the accumulation patterns of flavonoids and phenolic acids in quinoa (Chenopodium quinoa Willd.) grains of different colors. 2023. Food Chemistry X. doi.org/10.1016/j.fochx.2023.100594
Qian G., Wang M., Wang X., Liu K., Li Y., Bu Y. andLi Lixin*Integrated Transcriptome and Metabolome Analysis of Rice Leaves Response to High Saline–Alkali Stress. 2023. Int. J. Mol. Sci., 24, 4062.
Wang M, Zhang H, Zhao X, Zhou J, Qin G, Liu Y, Kou X, Zhao Z, Wu T, Zhu JK, Feng X.,Li Lixin*SYNTAXIN OF PLANTS81 regulates root meristem activity and stem cell niche maintenance via ROS signaling. 2022. Plant Physiology 10.1093/plphys/kiac530
Ma X., Zhao X., Zhang H., Zhang Y., Sun S., Li Y., Long Z., Liu Y., Zhang X., Li R., Tan L., Jiang., Zhu J–K. andLi Lixin*MAG2 and MAL Regulate Vesicle Trafficking and Auxin Homeostasis With Functional Redundancy. Frontiers in Plant Science. 2022. 13:849532.
Li Guan, Shurui Yang, Shenglin Li, Yu Liu, Yuqi Liu, Yi Yang, Guochen Qin, Haihai Wang, Tao Wu, Zhigang Wang, Xianzhong Feng, Yongrui Wu, Zhu J–K., Li X.,Li Lixin*. AtSEC22 Regulates Cell Morphogenesis via Affecting Cytoskeleton Organization and Stabilities. Frontiers in Plant Science. 2021. 12:635732.
Zhao X., Guo X., Tang X., Zhang H., Wang M., Kong Y., Zhang X., Zhao Z., Lv M. andLi Lixin*. Misregulation of ER-Golgi Vesicle Transport Induces ER Stress and Affects Seed Vigor and Stress Response. 2018. Frontiers in Plant Science. 9:658.
Chunlei Zhang, Zipeng Yu, Mengyue Zhang, Xiaoxuan Li, Mingjing Wang,Lixin Li, Xugang Li, Zhaojun Ding, and Huiyu Tian. Serratia marcescens PLR enhances lateral root formation through supplying PLR-derived auxin and enhancing auxin biosynthesis in Arabidopsis. Journal of Experimental Botany (2021)
Tang LP, Yang Y, Wang H,Li Lixin, Liu L, Liu Y, Yuan J, Zhao XY, Palme K, Su YH, Li X. AtNSF regulates leaf serration by modulating intracellular trafficking of PIN1 in Arabidopsis thaliana. J Integr Plant Biol. 2020 Dec 2;63(4):737-55.
Butt H, Piatek A,Li Lixin, S N Reddy A, M Mahfouz M. Multiplex CRISPR Mutagenesis of the Serine/Arginine-Rich (SR) Gene Family in Rice. Genes (Basel). 2019 Aug 7;10(8):596.
Ling Y, Alshareef S, Butt H, Lozano-Juste J,Li Lixin, Galal AA, Moustafa A, Momin AA, Tashkandi M, Richardson DN, Fujii H, Arold S, Rodriguez PL, Duque P, Mahfouz MM. Pre-mRNA splicing repression triggers abiotic stress signaling in plants. Plant Journal. 2017 Jan;89(2):291-309.
Ali Z, Abul-faraj A,Li Lixin,Ghosh N, Piatek M, Mahjoub A, Aouida M, Piatek A, Baltes NJ, Voytas DF, Dinesh-Kumar S, Mahfouz MM. Efficient Virus-Mediated Genome Editing in Plants Using the CRISPR/Cas9 System. Molecular Plant. 2015 Aug;8(8):1288-91
Lixin Li,Shimada Tomoo, Takahashi H, Koumoto Y, Shirakawa M, Takagi J, Zhao X, Tu B, Jin H, Shen Z, Han B, Jia M, Kondo M, Nishimura M, Hara-Nishimura I. MAG2 and three MAG2 INTERACTING PROTEINs form an ER-localized complex to facilitate the storage protein transport in Arabidopsis thaliana. (2013) Plant Journal 76(5):781-791.
Li Lixin, Atef A, Piatek A, Ali Z, Piatek M, Aouida M, Sharakuu A, Mahjoub A, Wang G, Khan S, Fedoroff NV, Zhu JK, Mahfouz MM. Characterization and DNA-binding specificities of Ralstonia TAL-like effectors. Molecular Plant. 2013 Jul;6(4):1318-30.
Li Lixin, Piatek MJ, Atef A, Piatek A, Wibowo A, Fang X, Sabir JS, Zhu JK, Mahfouz MM. Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification. Plant Mol Biol. 2012 Mar;78(4-5):407-16.
Mahfouz MM,Li Lixin. TALE nucleases and next generation GM crops. GM Crops. 2011 Apr-Jun;2(2):99-103.
Piatek A, Ali Z, Baazim H,Li Lixin, Abulfaraj A, Al-Shareef S, Aouida M, Mahfouz MM. RNA-guided transcriptional regulation in planta via synthetic dCas9-based transcription factors. Plant Biotechnol J. 2015 May;13(4):578-89.
Mahfouz MM,Li Lixin, Piatek M, Fang X, Mansour H, Bangarusamy DK, Zhu JK. Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein. Plant Mol Biol. 2012 Feb;78(3):311-21.
Aouida M,Li Lixin, Mahjoub A, Alshareef S, Ali Z, Piatek A, Mahfouz MM. Transcription activator-like effector nucleases mediated metabolic engineering for enhanced fatty acids production in Saccharomyces cerevisiae. J Biosci Bioeng. 2015 Oct;120(4):364-71.
Mahfouz MM,Li Lixin,Shamimuzzaman M, Wibowo A, Fang X, Zhu JK. De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2623-8.
Li Lixin, Shimada, T., Takahashi, H., Ueda, H., Fukao, Y., Kondo, M., Nishimura M., Hara-Nishimura I. MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana. 2006 .Plant Cell 18, 3535–3547. doi: 10.1105/tpc. 106.046151
授權專利
國家專利1:一株簡氏氣單胞菌及其在提高植物抗逆性中的應用,專利号:ZL 2018 1 1318050.9
國家專利2:一株不動杆菌及其在提高植物抗逆性中的應用,專利号:ZL202111571225.9
國家專利3:一株希瓦氏菌及其在提高植物抗逆性中的應用, 專利号:ZL 201910401921.1