史金銘副教授，碩士生導師，副院長，專業負責人
聯系方式：
E-mail: jmshi@nefu.edu.cn
電話：13384664535
地址：黑龍江省哈爾濱市香坊區和興路26号
伟德官网下app官方网站（新逸夫教學樓）117房間
教育和訓練經曆:
1997/09－2001/07，吉林大學，生物化學，理學學士
2001/09－2004/07，吉林大學，酶工程，理學碩士
2005/3－2010/03，哈爾濱工業大學，生物技術，工學博士
工作經曆：
2010/07－2016/09，伟德官网下app官方网站，伟德官网下app官方网站，講師
2016/09－至今，伟德官网下app官方网站，伟德官网下app官方网站，副教授
專業特長:
生物化學，表觀遺傳學，分子生物學
研究經驗和研究領域:
主要研究植物小分子化合物的生物活性和抗癌機制。相關成果發表在Phytomedicine、Curr Cancer Drug Targets等期刊上。參加國家自然科學基金面上項目3項，黑龍江省自然科學基金重點項目1項。主持省自然科學基金3項，省教育廳課題1項，中央高校課題2項。
教學情況:
承擔本科生課程《生物化學A》、《生物化學實驗》和《生化分析技術》；留學生課程《Experimental Techniques of Current Biology》和《Current Progress in Molecular Biology》的部分講課内容。
承擔的主要課題:
1）國家自然科學基金面上項目，SOX7在乳腺癌中調控機制的研究（81472635）2015.01‐2018.12；第二參與人：史金銘。
2）國家自然科學基金面上項目，乳腺癌中YY1調節促癌蛋白活性的機制及其應用價值的研究（81672795）2017.01‐2020.12；第二參與人：史金銘。
3）國家自然科學基金面上項目，乳腺癌中YY1調節促癌蛋白活性的機制及其應用價值的研究（81672795）2017.01-2020.12；第二參與人：史金銘。
4）黑龍江省自然科學基金面上項目：藥物誘導低DNA甲基化對植物抗氧化性的影響（C201108）2012.01-2014.12；負責人：史金銘。
5）黑龍江省自然科學基金青年項目：利用小鼠移植瘤模型研究miR-15a/16對乳腺癌中脂肪酸合酶的抑制及其臨床應用價值，（QC2016100）2016.07-2019.10；負責人：史金銘。
6）黑龍江省自然科學基金聯合引導項目：利用多肽幹擾EZH2與YY1的結合抑制乳腺癌的分子機制研究（LH2020H002）；2020.07-2023.07；負責人：史金銘。
主要發表文章:
1. Jinming Shi, Aixin Hao, Qiang Zhang, and Guangchao Sui*. The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies. Current Cancer Drug Targets. (2015) 15(2):145-157.
2. Qiang Zhang, Meimei Wan, Jinming Shi, David A. Horita, Lance D. Miller, Timothy E. Kute, Steven J. Kridel, George Kulik, and Guangchao Sui*. Yin Yang 1 Promotes mTORC2-mediated AKT Phosphorylation. J. Mol. Cell. Biol. (2016) 8(3):232-243.
3. Jingxuan Wang, Xiao Zhang, Jinming Shi, Paul Cao, Meimei Wan, Qiang Zhang, Yunxuan Wang, Steven J. Kridel, Wennuan Liu, Jianfeng Xu, Qingyuan Zhang and Guangchao Sui*. Fatty Acid Synthase is a Primary Target of MiR-15a and MiR-16-1 in Breast Cancer. Oncotarget. (2016) 7(48):78566-78576.
4. Na Tian, Jialiang Li, Jinming Shi and Guangchao Sui*. From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform. (2017) Int. J. Mol. Sci. 18(191):1-20.
5. Yingzhou Li, Xiao Zhang, Yang Gao, Jiming Shi and Guangchao Sui*. G-quadruplexes in the BAP1 promoter positively regulate its expression. Exp. Cell. Res. (2018) 369(1):147-15.
6. Yige Qi, Ting Yan, Lu Chen, Qiang Zhang, Weishu Wang, Xu Han, Dangdang Li, Jinming Shi and Guangchao Sui*. Characterization of YY1 OPB Peptide for Its Anticancer Activity, Current Cancer Drug Targets, (2019) 19(6):504-511.
7. Chen Zhong, Shuang Qiu, Jialiang Li, Jingling Shen, Yuangang Zu, Jinming Shi* and Guangchao Sui*. Ellagic acid synergistically potentiates inhibitory activities of chemotherapeutic agents to human hepatocellular carcinoma. Phytomedicine, (2019) 59:152921.
8. Ting Yan, Bo Zhao, Qiong Wu, Wenmeng Wang, Jinming Shi, Dangdang Li, Daniel B. Stovall and Guangchao Sui*. Characterization of G-quadruplex formation in the ARID1A promoter. Int J Biol Macromol. (2020) 147:750-761.
9. Yunxuan Wang, Ting Yan, Jialiang Li, Wenmeng Wang, Qiong Wu, Jinming Shi, Dangdang Li, Daniel B. Stovall, Qingyuan Zhang* and Guangchao Sui*. The SNAIL1 promoter contains G-quadruplex structures regulating its gene expression and DNA replication. Exp Cell Res. (2020) 394(2):112158.
10. Qiong Wu, Bo Zhao, Guangchao Sui* and Jinming Shi*. Phytochemicals block glucose utilization and lipid synthesis to counteract metabolic reprogramming in cancer cells. Applied Sciences. (2021) 11:1259.
11. Cheng Yi, Guangyue Li, Wenmeng Wang, Yixuan Sun, Yueling Zhang, Chen Zhong, Daniel B. Stovall, Dangdang Li, Jinming Shi* and Guangchao Sui*. Disruption of YY1-EZH2 Interaction Using Synthetic Peptides Inhibits Breast Cancer Development. Cancers. (2021) 13(10):2402.
12. Jialiang Li, Guangyue Li, Yige Qi, Yao Lu, Hao Wang, Ke Shi, Dangdang Li, Jinming Shi, Daniel B. Stovall and Guangchao Sui*. SRSF5 Regulates Alternative Splicing of DMTF1 pre-mRNA through Modulating SF1 Binding. RNA Biology. (2021) 18(sup1):318-336..
13. Bo Zhao, Jinyan Zhao, Mingshuai Lv, Xiaoyan Li, Jinhua Wang, Zhengrong Yue, Jinming Shi, Guocai Zhang* and Guangchao Sui*. Comparative study of structural properties and biological activities of polysaccharides extracted from Chroogomphus rutilus by four different approaches. Int J Biol Macromol. (2021) 188:215-225.
14. Jinhua Wang, Dangdang Li, Bo Zhao, Juhyok Kim, Guangchao Sui*, Jinming Shi*. Small molecule compounds of natural origin target cellular receptors to inhibit cancer development and progression. Int J Mol Sci. (2022) 23(5): 2672.
