聶玉哲,講師
聯系方式:
E-mail:nieyuzhe@163.com
地址:黑龍江省哈爾濱市香坊區和興路26号
伟德官网下app官方网站(新逸夫教學樓)136房間
教育和訓練經曆:
1999/09-2003/07伟德官网下app官方网站,生物科學專業(國家生物科學理科基地班),理學學士
2003/09-2006/07伟德官网下app官方网站,園林植物與觀賞園藝,農學碩士
2006/09-2010/07伟德官网下app官方网站,發育生物學,理學博士
2009/01-2009/06赫爾辛基大學,聯合培養博士
2015/07-2016/10南卡羅萊納大學,博士後
工作經曆:
2010/07至今,講師
專業特長:
細胞生物學、蛋白質組學、分子生物學
●教學情況:
主講本科《動物細胞工程與原理》、《細胞生物學實驗課程》。參編教材《現代分子生物學實驗模塊指南》和《蛋白質分析實驗技術指南》。
●科學研究方向:
胰腺癌細胞的增殖與抑制。
●近年研究課題:
microRNA124調控微量金屬元素吸收抑制胰腺癌細胞的機制研究,黑龍江省重點基金,2017.10-2020.10。參加
●近年發表文章:
1. Lin Yang, Delin Kong, Mei He, Jiawei Gong, Yuzhe Nie, Sheng Tai, Chun-Bo Teng. MiR-7 mediates mitochondrial impairment to trigger apoptosis and necroptosis in Rhabdomyosarcoma. Biochim Biophys Acta Mol Cell Res. 2020; doi:10.1016/j.bbamcr.2020.118826
2. Ze Yu, Hao Wang, Yilin Fang, Liangliang Lu, Minghao Li, Bingru Yan, Yuzhe Nie and Chunbo Teng. Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. Journal of Cellular Biochemistry. 2020, 121(3): 2318-2329.
3. Miao Liu, Wen Yu, Jing Jin, Mingjun Ma, Tiezhu An, Yuzhe Nie and Chun-Bo Teng. Copper promotes sheep pancreatic duct organoid growth by activation of an antioxidant protein 1-dependent MEK-ERK pathway. American Journal of Physiology-Cell Physiology. 2020, 318(4): C806-C816.
4.Yang L, Zhu Y, Kong D, Gong J, Yu W, Liang Y, Nie Y, Teng C-B: EGF suppresses the expression of miR-124a in pancreatic beta cell lines via ETS2 activation through the MEK and PI3K signaling pathways. International Journal Of Biological Sciences 2019, 15:2561-2575.
5.Yu Z, Wang H, Fang Y, Lu L, Li M, Yan B, Nie Y, Teng C: Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. Journal Of Cellular Biochemistry 2019.
6. Yu Z, Yu Z, Chen Z, Yang L, Ma M, Lu S, Wang C, Teng C, Nie Y: Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy. Journal Of Cellular Physiology 2019, 234:20648-20661.
7. Zhou RT, He M, Yu Z, Liang Y, Nie YZ, Tai S, Teng CB: Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways. Oncotarget 2017, 8:56351-56363.