報告題目：Dynamics of Stem Cell Signaling Pathways in Meristems
報 告 人：Rüdiger Simon教授 德國杜塞爾多夫大學，遺傳學研究所，Cluster of Excellence on Plant Sciences負責人
報告時間：2015年12月17日（周四）下午14：00分
報告地點：伟德官网下app官方网站新逸夫教學樓608會議室
報告人簡曆：
Rüdiger Simon教授，男，現任德國杜塞爾多夫大學，遺傳學研究所，Cluster of Excellence on Plant Sciences負責人、Center for Advanced Imaging (CAi)中心負責人及Developmental Genetics實驗室負責人。Simon實驗室以拟南芥、油菜籽和短柄草為模型，主要進行植物發育方向的研究，重點緻力于植物幹細胞信号傳導、器官分化起始以及在發育過程中時空水平上細胞命運決定機制的研究。研究成果在Nature、Science、 Cell等頂級刊物上多次發表，對植物幹細胞領域的研究有重大影響。
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Simon教授的講座摘要:
Dynamics of stem cell signaling pathways in meristems
Organogenesis in plants is based on precise cell fate determination of undifferentiated cells, which are derived from stem cells that reside in meristems. Cell fate determination depends on the position of a cell within the plant body. A number of mechanisms provide positional information to cells or cell populations: (1) plant hormones like auxin establish gradients or local concentration maxima; (2) secreted ligands and membrane associated receptors enables cell-cell signaling between adjacent cell layers; (3) transcription factors can act non-cell autonomously to integrate cellular responses, and (4) long range communication takes place by transport of signals between cells through plasmodesmata.
Our current understanding is that these mechanisms act in a concerted manner to govern plant development. I will report on our most recent results on receptor kinase signaling pathways that control the growth and maintenance of meristems. Using a toolbox of fluorescence imaging techniques in planta, we studied the dynamics of receptor assembly into larger complexes at distinct regions of the plasmamembranes upon the perception of their specific ligands. Furthermore, we found that alterations of receptor expression levels can have profound developmental consequences. Finally, I will try to link aspects of peptide-receptor and hormonal signaling pathways, and highlight important commonalities and differences between developmental and pathogen response pathways.
