劉成偉教授，博士生導師

聯系方式：

E-mail:liuchw@nefu.edu.cn

地址：黑龍江省哈爾濱市香坊區和興路26号

伟德官网下app官方网站(新逸夫教學樓) 617房間

工作及教育經曆:

2009/11 ~至今伟德官网下app官方网站 教授

2015/11 ~ 2019/09北海道大學大學院理學研究院化學部門助理教授

2014/04 ~ 2015/10日本北海道大學大學院理學研究院化學部門博士後

2011/04 ~ 2014/03日本北海道大學,綜合化學院博士

2009/04 ~ 2011/03日本秋田縣立大學,生物資源研究科碩士

2008/03 ~ 2009/03日本秋田縣立大學,生物資源研究科研究生

2004/08 ~ 2008/02東陽光集團制藥部門研究員

專業特長:

合成生物學，天然産物化學，次級代謝産物生物合成途徑解析，異源合成。

研究經驗和研究領域:

植物，微生物生産的天然産物是重要的醫藥資源，為人類的健康做出了巨大的貢獻，本課題組主要研究内容是天然産物的生物合成途徑解析。通過基因組編輯技術（CRISPR/Cas9）和米曲黴異源表達的方法，對具有生理活性物質的生物合成途徑進行分析，解明酶促反應機理。探索和激活具有潛在功能的基因，挖掘新的天然産物。并且通過基因編輯以及異源表達等方法，高效生産具有應用價值的化合物。研究内容主要歸納為以下幾個方向：

研究方向一：大型真菌（蘑菇）次級代謝産物的生物合成途徑解析：

許多蘑菇菌類具有廣泛的醫用價值，比如自古以來就被用于中藥藥材的靈芝，桑黃等，具有解毒，活血，增強免疫力，抗衰老等功效。但具有這些功效的天然産物還沒有完全被确定，這是由于蘑菇對栽培條件要求苛刻，基因操作困難，導緻蘑菇菌類生産的天然産物的生物合成研究相對匮乏。我們最近應該米曲黴表達系統，成功解明了猴頭菇生産的猴頭菌素（erinacine）的生物合成途徑。在此基礎上将繼續對有應用價值的大型真菌生産的天然産物生物合成途徑進行研究。

研究方向二：激活具有潛在功能基因，挖掘新化合物：

近年來，随着基因組技術的發展，必要的基因組信息可以在短時間内獲得。通過這些信息可以清楚地看到，存在于微生物中的許多次級代謝産物生物合成基因的轉錄活性受到了抑制。例如，絲狀真菌Aspergillus flavus的全基因組中預測存在30種以上次級代謝産物生物合成基因簇，但實際上隻有少數幾種被識别。在許多情況下，大多數生物合成基因處于休眠狀态，并不能确認生産天然産物。通過異源表達方式，不僅可以解明已知天然産物的生物合成途徑，還可以通過激活具有潛在功能的基因簇，挖掘新的代謝産物。

研究方向三：高效合成具有應用價值的化合物：

“合成生物學”理論和技術極大的推動了生物技術領域的發展，被意為可改變世界的十大新技術之一，是影響未來的颠覆性技術，極大的促進了生物制造領域的創新發展。通過我們對基因的挖掘，明确酶的功能和反應機理，将來可以定向的對酶進行改造，将不同來源的生物相關代謝途徑模塊化，并在底盤上進行組裝，設計合适的生物合成路徑，提高代謝途徑的效率，降低大規模生物催化反應的成本，實現各種重要次級代謝産物高效生物合成和規模化生産。

教學情況:

主講本科生《微生物學》、《科學道德》；研究生《合成生物學》、《高級微生物學專題》等課程。

近年承擔的主要課題:

1.國家自然科學基金面上項目(主持):猴頭菌酮類大型真菌雜萜的生物合成途徑解析及其異源重構（32370069, 2024.01~2027.12）；

2.國家自然科學基金區域創新發展聯合基金重點支持項目(子課題負責人):基于“活性機制-資源評價-代謝合成”的寒地道地藥材稀有皂苷應用基礎研究(U22A20369, 2023.01~2026.12)；

3.黑龍江省自然科學基金聯合引導項目(主持):吲哚二萜類化合物環化機理與多樣性形成機制的研究（LH2023C035, 2023.07~2026.07）；

4.山東省自然科學基金重點項目(參與)：抗阿爾茨海默藥物先導化合物的異源生物合 成與作用機理研究(ZR2021LSW022, 2022.01~2024.12)；

5.校企聯合橫向課題(主持)，胞磷膽堿鈉及核苷酸原料酶法生産工藝開發,（HKF220150002，2022.04~2023.04）;

6.日本學術振興會青年基金(主持),蘑菇類生産的醫藥候補品萜類化合物生産法的開發(18K14342, 2018.04 ~ 2020.03);

7.日本學術振興會青年基金B(主持),吲哚二萜類天然化合物生物合成過程中多樣性形成 的機理和調控解析(16K16636, 2016.04 ~ 2018.03)

主要發表文章: (*為通訊作者)

2024年

1.Jianzhao Qi, Jing Wu, Shi-jie Kang, Jing-ming Gao, Hirokazu Kawagishi, Hongwei Liu,Chengwei Liu*.

The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genusHericium: A review.Chin J Nat Med.2024,22(0): 1-24. doi:10.1016/S1875-5364(24)60590-X.

2.Jian-zhao Qi, Shi-jie Kang, Ling Zhao, Jin‑ming Gao &Chengwei Liu*.

Natural and engineered xylosyl products from microbial source.Nat. Prod. Bioprospect.2024, 14, 13. doi.org/10.1007/s13659-024-00435-1.

3.Yang, Hui, Chaonan Song,Chengwei Liu*, and Pengchao Wang*.

Synthetic Biology Tools for Engineering Aspergillus oryzae.J. Fungi.2024, 10,34. doi.org/10.3390/jof10010034.

2023年

4.Liqiu Zhang, Meixia Yan &Chengwei Liu*.

A comprehensive review of secondary metabolites from the genusAgrocybe: Biological activities and pharmacological implications.Mycology.2023. DOI: 10.1080/21501203.2023.2292994.

5.Ji-Shuang Qi, Yingce Duan, Zhao-Chen Li, Jin-Ming Gao, Jianzhao Qi*,Chengwei Liu*.

The alkynyl-containing compounds from mushrooms and their biological activities.Nat Prod Bioprospect.2023,13(1),50. doi: 10.1007/s13659-023-00416-w.

6.Haiyan Han, Chunyan Yu, Jianzhao Qi, Pengchao Wang, Peipei Zhao, Wenbing Gong, Chunliang Xie, Xuekui Xia*,Chengwei Liu*.

High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae.Microb Cell Fact.2023,22, 60. doi: 10.1186/s12934-023-02071-9.

7.Jianzhao Qi, Yu-Qi Gao, Shi-Jie Kang,Chengwei Liu*, Jin-Ming Gao*.

Secondary Metabolites of Bird's Nest Fungi: Chemical Structures and Biological Activities.J Agric Food Chem.2023,71, 6513-6524.doi: 10.1021/acs.jafc.3c00904.

8.Chunyan Yu^#, Jianzhao Qi^#, Haiyan Han, Pengchao Wang*,Chengwei Liu*.

Progress in pathogenesis research of Ustilago maydis, and the metabolites involved along with their biosynthesis.Mol Plant Pathol.2023 Feb 17. doi: 10.1111/mpp.13307.

9.Jingwen Niu, Jianzhao Qi, Pengchao Wang,Chengwei Liu*, Jin-Ming Gao*.

The chemical structures and biological activities of indole diterpenoids.Nat Prod Bioprospect.2023, 13(1), 3. doi: 10.1007/s13659-022-00368-7.

10.Cha Cao, Dengfan Lin, Yingjun Zhou, Na Li, Yiwen Wang, Wenbeng Gong, Zuohua Zhu,Chengwei Liu, Li Yan, Zhenxiu Hu, Yuande Peng, Chunliang Xie*.

Solid-state fermentation of Apocynum venetum L. by Aspergillus niger: Effect on phenolic compounds, antioxidant activities and metabolic syndrome-associated enzymes.Front Nutr.2023, 10:1125746. doi: 10.3389/fnut.2023.1125746.

11.周一鳴，祁建钊，段應策，趙敏,劉成偉*.

大型擔子菌中二萜化合物生物合成研究進展.《菌物學報》,2023,44(1):101-117. doi: 10.13346/j.mycosystema.220374

2022年

12.Yingce Duan, Jianzhao Qi, Jin-Ming Gao,Chengwei Liu*.

Bioactive components of Laetiporus species and their pharmacological effects.

Appl Microbiol Biotechnol.2022, 106(18):5929-5944.doi: 10.1007/s00253-022-12149-w.

13.Yingce Duan, Haiyan Han, Jianzhao Qi, Jin-Ming Gao, Zhichao Xu, Pengchao Wang, Jie Zhang,Chengwei Liu*.

Genome sequencing of Inonotus obliquus reveals insights into candidate genes involved in secondary metabolite biosynthesis. BMC Genomics.2022，23(1):314. doi: 10.1186/s12864-022-08511-x.

14.Ping Zhang, Jianzhao Qi, Yingce Duan, Jin-Ming Gao*,Chengwei Liu*.

Research Progress on Fungal Sesterterpenoids Biosynthesis.J. Fungi.2022，8(10), 1080; https://doi.org/10.3390/jof8101080.

15.Jiajun Wu, Xiaoran Yang, Yingce Duan, Pengchao Wang, Jianzhao Qi, Jin-Ming Gao,Chengwei Liu*.

Biosynthesis of Sesquiterpenes in Basidiomycetes: A Review.J. Fungi.2022，8(9), 913; https://doi.org/10.3390/jof8090913.

16.Jianzhao Qi, Haiyan Han, Dan Sui, Shengnan Tan, Changli Liu, Pengchao Wang, Chunliang Xie, Xuekui Xia, Jin-ming Gao*,Chengwei Liu*.

Efficient production of a cyclic dipeptide (cyclo-TA) using heterologous expression system of filamentous fungus Aspergillus oryzae.Microb Cell Fact.2022，21(1):146. doi: 10.1186/s12934-022-01872-8.

17.Pengchao Wang, Xiwen Zhang, Yucheng Tao, Xubing Lv, Shengjie Cheng,Chengwei Liu*.

Improved l-phenylglycine synthesis by introducing an engineered cofactor self-sufficient system.Synth Syst Biotechnol.2022, 7(1):513-521. doi: 10.1016/j.synbio.2021.12.008.

18.Rui-qi Zhang; Xi-long Feng; Zhen-xin Wang; Tian-chen Xie; Yingce Duan;Chengwei Liu; Jin-ming Gao; Jianzhao Qi

Genomic and Metabolomic Analyses of the Medicinal Fungus Inonotus hispidus for Its Metabolite’s Biosynthesis and Medicinal Application.J. Fungi.2022，8(12), 1245; https://doi.org/10.3390/jof8121245.

19.Chunlei Wang, Sijia Wang, Jieru Zhang, Shumin Jiang, Daizong Cui, Haiqiong Sun,Chengwei Liu, Lili Li, Min Zhao*.

The Biodegradation of Indigo Carmine by Bacillus safensis HL3 Spore and Toxicity Analysis of the Degradation Products.Molecules2022, 27(23), 8539;https://doi.org/10.3390/molecules27238539.

20.Lan Jiang, Kangjie Lv, Guoliang Zhu, Zhi Lin, Xue Zhang, Cuiping Xing, Huanting Yang, Weiyan Zhang, Zhixin Wang,Chengwei Liu, Xudong Qu, Tom Hsiang, Lixin Zhang, Xueting Liu*.

Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae.Synth Syst Biotechnol.2022, 23, 7(4), 1142-1147.doi:10.1016/j.synbio.2022.08.002.

21.Lan Jiang, Huanting Yang, Xue Zhang, Xiaoying Li, Kangjie Lv, Weiyan Zhang, Guoliang Zhu,Chengwei Liu, Yongheng Wang, Tom Hsiang, Lixin Zhang, Xueting Liu*.

Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach.Appl Microbiol Biotechnol.2022, 106(18):6047-6057.doi: 10.1007/s00253-022-12125-4.

22.Zhenxin Wang, Xilong Feng,Chengwei Liu, Jinming Gao, Jianzhao Qi*.

Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus.Antibiotics2022,11(8):1097.doi: 10.3390/antibiotics11081097.

23.韓海燕,段應策,彭爽,祁建钊,劉成偉*

炭角菌屬次生代謝産物及藥理活性研究進展

《世界科學技術-中醫藥現代化》,2022, DOI：10.11842/wst.20211109005

24.朱玥彤,高緒卿,李一冰,安百強,段應策,劉成偉*.

虎乳靈芝活性成分及藥理作用研究進展

《世界中醫藥》,2022,17(13):1846-1851.DOI：10.3969/j.issn.1673-7202.2022.13.009

25.段應策,隋丹,汪麟,張肖甯,汪春蕾,劉成偉*

桦褐孔菌小分子化合物化學成分及其藥用價值的研究進展

《菌物研究》,2022,20(03):214-227. doi: 10.13341/j.jfr.2021.1451.

2021年

26.Kaho Sogahata, Taro Ozaki, Yuya Igarashi, Yuka Naganuma,Chengwei Liu, Atsushi Minami, Hideaki Oikawa*.

Biosynthetic Studies of Phomopsins Unveil Posttranslational Installation of Dehydroamino Acids by UstYa Family Proteins.Angew Chem Int Ed Engl.,2021,60 (49), 25729-25734. doi: 10.1002/anie.202111076.

27.Yulu Jiang, Taro Ozaki,Chengwei Liu, Yuya Igarashi, Ying Ye, Shoubin Tang, Tao Ye, Jun-Ichi Maruyama, Atsushi Minami, Hideaki Oikawa*.

Biosynthesis of Cyclochlorotine: Identification of the Genes Involved in Oxidative Transformations and Intramolecular O, N-Transacylation.Org Lett.,2021, 23 (7), 2616-2620. doi: 10.1021/acs.orglett.1c00525.

28.Lan Jiang, Xue Zhang, Yuya Sato, Guoliang Zhu, Atsushi Minami, Weiyan Zhang, Taro Ozaki, Bin Zh, Zhixin Wang, Xinye Wang, Kangjie L, Jingyu Zhang, Yongheng Wang, Shushan Gao,Chengwei Liu, Tom Hsiang, Lixin Zhang, Hideaki Oikawa*, Xueting Liu*.

Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases.Org Lett.,2021, 23 (12), 4645-4650. doi: 10.1021/acs.orglett.1c01361.

29.Changli Liu, Xiaotong Wang, Hongyi Yang,Chengwei Liu, Zhi Zhang, Guoqiang Chen

Biodegradable polyhydroxyalkanoates production from wheat straw by recombinant Halomonas elongata A1.Int J Biol Macromol. 2021, 187, 675-682. doi: 10.1016/j.ijbiomac.2021.07.137.

30.Albert Gyapong Aduhene, Hongliang Cui, Hongyi Yang,Chengwei Liu, Guangchao Sui, Changli Liu. Poly(3-hydroxypropionate): Biosynthesis Pathways and Malonyl-CoA Biosensor Material Properties.Front Bioeng Biotechnol., doi: 10.3389/fbioe.2021.646995. 2021

31.類成智,韓海燕,劉成偉*,趙敏*

毛韌革菌次生代謝産物研究進展

《菌物學報》, 2021, 40 (8), 1918-1937. doi: 10.13346/j.mycosystema.210136

32.李恩楷,類成智,朱登軒,劉昱婷,劉成偉*.

阿特匹林C生物合成與活性研究進展

《海南醫學》,2022,33(02):235-239.DOI：10.3969/j.issn.1003-6350.2022.02.027

2020年

33.Lei Gao, Cong Su, Xiaoxia Du, Ruishan Wang, Shuming Chen, Yu Zhou,Chengwei Liu, Xiaojing Liu, Runze Tian, Liyun Zhang, Kebo Xie, She Chen, Qianqian Guo, Lanping Guo, Yoshio Hano, Manabu Shimazaki, Atsushi Minami, Hideaki Oikawa, Niu Huang, K N Houk, Luqi Huang*, Jungui Dai*, Xiaoguang Lei*.

FAD-dependent Enzyme-Catalysed Intermolecular [4+2] Cycloaddition in Natural Product Biosynthesis.Nat Chem., 2020, doi: 10.1038/s41557-020-0467-7.

34.Yulu Jiang, Taro Ozaki, Mei Harada, Tadachika Miyasaka, Hajime Sato, Kazunori Miyamoto, Junichiro Kanazawa,Chengwei Liu, Jun-Ichi Maruyama, Masaatsu Adachi, Atsuo Nakazaki, Toshio Nishikawa, Masanobu Uchiyama, Atsushi Minami, Hideaki Oikawa*.

Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton.Angew Chem Int Ed Engl.,2020, 59 (41), 17996-18002. DOI: 10.1002/anie.202007280

35.Tetsuya Shiina, Taro Ozaki, Yusuke Matsu, Shota Nagamine,Chengwei Liu, Masaru Hashimoto, Atsushi Minami, Hideaki Oikawa*.

Oxidative Ring Contraction by a Multifunctional Dioxygenase Generates the Core Cycloocatadiene in the Biosynthesis of Fungal Dimeric Anhydride Zopfiellin.Org Lett.,22(5),1997-2001, 2020. DOI: 10.1021/acs.orglett.0c00340

36.Takahiro Ugai, Atsushi Minami，Shizuya Tanaka，Taro Ozaki，Chengwei Liu，Hideyuki Shigemori，Masaru Hashimoto, Hideaki Oikawa*.

Biosynthetic machinery of 6‐hydroxymellein derivatives leading to cyclohelminthols and palmaenones.ChemBioChem.21 (3), 360-367,2020. doi: 10.1002/cbic.201900404.

37.Chengwei Liu, Atsushi Minami, Taro Ozaki, and Hideaki Oikawa

Biosynthesis of indole diterpenes.Comprehensive Natural Products III: Chemistry and Biology.2020, vol. 2, pp. 446-466.DOI:10.1016/b978-0-12-409547-2.14685-2.

2019年

38.Chengwei Liu, Atsushi Minami, Taro Ozaki, Jing Wu, Hirokazu Kawagishi, Jun-ichi Maruyama, Hideaki Oikawa*.

Efficient reconstitution of Basidiomycota diterpene erinacine gene cluster in Ascomycota hostAspergillus oryzaebased on genomic DNA sequences.J.Am. Chem. Soc.,141 (39), 15519-15523,2019. doi: 10.1021/jacs.9b08935.

39.Shota Nagamine,Chengwei Liu, Jumpei Nishishita, Takuto Kozaki, Kaho Sogahata, Yoshiro Sato, Atsushi Minami, Taro Ozaki, Claudia Schmidt-Dannert, Jun-ichi Maruyama, Hideaki Oikawa*.

Ascomycota Aspergillus oryzae is an efficient expression host for production of Basidiomycota terpenes using genomic DNA sequences.Appl Environ Microbiol.,85 (15), e00409-19, 2019. DOI: 10.1128/AEM.00409-19

40.Junya Takino, Takuto Kozaki, Taro Ozaki,Chengwei Liu, Atsushi Minami, Hideaki Oikawa*.

Elucidation of biosynthetic pathway of a plant hormone abscisic acid in phytopathogenic fungi.Biosci. Biotech. Biochem.83 (9), 1642-1649, 2019. DOI:10.1080/09168451.2019.1618700.

41.Ying Ye, Taro Ozaki, Myco Umemura,Chengwei Liu, Atsushi Minamia, Hideaki Oikawa*.

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase.Org Biomol Chem., 17(1), 39-43, 2019. DOI: 10.1039/c8ob02824a

42.Tetsuya Shiina, Kazuya Nakagawa, Yukiko Fujisaki, Taro Ozaki,Chengwei Liu, Tomonobu Toyomasu, Masaru Hashimoto, Hiroyuki Koshino, Atsushi Minami, Hiroshi Kawaide & Hideaki Oikawa*.

Biosynthetic study of conidiation-inducing factor conidiogenone: heterologous production and cyclization mechanism of a key bifunctional diterpene synthase.Biosci Biotechnol Biochem.83 (2), 192-201,2019. DOI: 10.1080/09168451.2018.1536518

43.南篤志,尾崎太郎,劉成偉,及川英秋*.

糸狀菌による植物ホルモンアブシジン酸の生合成・新奇な環化酵素の発見.バイオサイエンスとインダストリー,77(2), 136-138, 2019.

2018年

44.Atsushi Minami*, Taro Ozaki,Chengwei Liu, Hideaki Oikawa*.

Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants.Nat Prod Rep. 35 (12), 1330-1346, 2018. DOI: 10.1039/c8np00026c.

45.Junya Takino, Takuto Kozaki, Yoshiro Sato,Chengwei Liu, Taro Ozaki, Atsushi Minami*, Hideaki Oikawa*.

Unveiling Biosynthesis of the Phytohormone Abscisic Acid in Fungi: Unprecedented Mechanism of Core Scaffold Formation Catalyzed by an Unusual Sesquiterpene Synthase.J. Am. Chem. Soc.,140 (39), 12392-12395, 2018. DOI: 10.1021/jacs.8b08925

46.Akihiro Tazawa, Ying Ye, Taro Ozaki,Chengwei Liu, Yasushi Ogasawara, Tohru Dairi, Yusuke Higuchi, Nobuo Kato, Katsuya Gomi, Atsushi Minami, and Hideaki Oikawa*.

Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification.Org. Lett.20 (19), 6178-6182, 2018. DOI: 10.1021/acs.orglett.8b02654

47.Kosei Kudo,Chengwei Liu, Tomoyuki Matsumoto, Atsushi Minami, Taro Ozaki, Hiroaki Toshima, Katsuya Gomi, Hideaki Oikawa*.

Heterologous biosynthesis of fungal indole sesquiterpene sespendole.Chembiochem.19 (14), 1492-1497, 2018. DOI: 10.1002/cbic.201800187

48.Taro Ozaki, Sandip S. Shinde, Lei Gao, Ryo Okuizumi,Chengwei Liu,Yasushi Ogasawara, Xiaoguang Lei, Tohru Dairi, Atsushi Minami, Hideaki Oikawa*.

Enzymatic formation of a skipped methyl‐substituted octaprenyl side chain of longestin (KS‐505a): Involvement of homo‐IPP as a common extender unit.Angew. Chem. Int. Ed. Engl.57 (22), 6629-6632,2018. DOI: 10.1002/anie.201802116

49.Koji Narita, Atsushi Minami, Taro Ozaki,Chengwei Liu, Motoichiro Kodama, Hideaki Oikawa*.

Total Biosynthesis of Antiangiogenic Agent (−)-Terpestacin by Artificial Reconstitution of the Biosynthetic Machinery inAspergillus oryzae.J. Org. Chem.83(13), 7042-7048. 2018. DOI: 10.1021/acs.joc.7b03220

50.Lei Gao, Koji Narita, Taro Ozaki, Naoyoshi Kumakura, Pamela Gan, Atsushi Minami,Chengwei Liu, Xiaoguang Lei, Ken Shirasu, Hideaki Oikawa*.

Identification of novel sesterterpenes by genome mining of phytopathogenic fungiPhomaandColletotrichumsp.

Tetrahedron Letters. 59 (12), 1136-1139, 2018. https://doi.org/10.1016/j.tetlet.2018.02.022

51.南篤志,尾崎太郎,劉成偉,及川英秋*.

糸狀菌テルペン環化酵素遺伝子のゲノムマイニングによる新規天然物の生産.バイオサイエンスとインダストリー,76(1), 20-25, 2018.

52.南篤志,劉成偉,尾﨑太郎,及川英秋.

酵母菌・麹菌・乳酸菌の産業応用展開(分擔執筆部分:麹菌を宿主としたカビの二次代謝化合物の生産).シーエムシー出版社, 2018年1月.

2017年以前

53.Momoka Yamane, Atsushi Minami,Chengwei Liu, Taro Ozaki, Ichiro Takeuchi, Tae Tsukagoshi, Tetsuo Tokiwano, Katsuya Gomi, Hideaki Oikawa*.

Biosynthetic machinery of diterpene pleuromutilin isolated from basidiomycete fungi.Chembiochem. 18 (23), 2317-2322, 2017.DOI: 10.1002/cbic.201700434

54.Koji Narita, Hajime Sato, Atsushi Minami, Kosei Kudo, Lei Gao,Chengwei Liu, (他8人).

Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products.Org. Lett. 19 (24), 6696–6699, 2017. DOI: 10.1021/acs.orglett.7b03418.

55.Chengwei Liu, Atsushi Minami, Tohru Dairi, Katsuya Gomi, Barry Scott, Hideaki Oikawa*.

Biosynthesis of Shearinine: Diversification of a Tandem Prenyl Moiety of Fungal Indole Diterpenes.Org. Lett.18 (19), 5026-5029, 2016. DOI: 10.1021/acs.orglett.6b02482.

56.Atsushi Minami,Chengwei Liu, Hideaki Oikawa*.

Total Biosynthesis of Fungal Indole Diterpenes Using Cell Factories.Heterocycles.92 (3), 397-421, 2016.DOI:10.1002/CHIN.201617243

57.Chengwei Liu, Koichi Tagami, Atsushi Minami, Tomoyuki Matsumoto, Jens Christian Frisvad, Hideyuki Suuki, Jun Ishikawa, Katsuya Gomi, Hideaki Oikawa*.

Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem.Angew. Chem. Int. Ed. Engl. 54 (19), 5748-52, 2015. DOI: 10.1002/anie.201501072.

58.Ying Ye, Atsushi Minami, Attila Mandi,Chengwei Liu, Tohru Taniguchi, Tomohisa Kuzuyama, Kenji Monde, Katsuya Gomi, and Hideaki Oikawa*. Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes.J. Am. Chem. Soc.137(36), 11846-53, 2015. DOI: 10.1021/jacs.5b08319

59.南篤志,劉成偉,及川英秋*.

麹菌異種発現系を利用した糸狀菌由來天然物の生産.

バイオサイエンスとインダストリー,73(6), 467-470, 2015.

60.Chengwei Liu, Motoyoshi Noike, Atsushi Minami, Hideaki Oikawa, Tohru Dairi*. A fungal prenyltransferase catalyzes the regular di-prenylation at positions 20 and 21 of paxilline.Biosci. Biotechnol. Biochem.78 (4), 448-54, 2014. doi:10.1080/09168451.2014.882759.

61.Chengwei Liu, Motoyoshi Noike, Atsushi Minami, Hideaki Oikawa, Tohru Dairi*. Functional analysis of a prenyltransferase gene (paxD) in the paxilline biosynthetic gene cluster.Appl. Microbiol. Biotechnol.98 (1), 199-06, 2014. DOI:10.1007/s00253-013-4834-9.

62.Koichi Tagami, Atsushi Minami, Ryuya Fujii,Chengwei Liu, Mizuki Tanaka, Katsuya Gomi, Tohru Dairi, Hideaki Oikawa*.

Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites in Aspergillus oryzae: Total Biosynthesis of Aflatrem.ChemBioChem.15(14), 2076-80, 2014.DOI: 10.1002/cbic.201402195.

63.Chengwei Liu, Atsushi Minami, Motoyoshi Noike, Hiroaki Toshima, Hideaki Oikawa, Tohru Dairi*.

Regiospecificities and prenylation mode specificities of the fungal indole diterpene prenyltransferases AtmD and PaxD.Appl. Environ. Microbiol.79 (23), 7298-304, 2013. doi: 10.1128/AEM.02496-13.

64.Chengwei Liu, Tatsuya Fukumoto, Tadashi Matsumoto, Patrizia Gena, Daniele Frascaria, Tomoyuki Kaneko, Maki Katsuhara, Shihua Zhong, Xiaoli Sun, Yanming Zhu, Ikuko Iwasaki, Xiaodong Ding, Giuseppe Calamita*, Yoshichika Kitagawa*. Aquaporin OsPIP1;1 promotes rice salt resistance and seed germination.Plant. Physiol. Biochem.63, 151-158, 2013. doi: 10.1016/j.plaphy.2012.11.018.

65.Koichi Tagami,Chengwei Liu, Atsushi Minami, Motoyoshi Noike, Tetsuya Isaka, Shuhei Fueki, Yoshihiro Shichijo, Hiroaki Toshima , Katsuya Gomi, Tohru Dairi, Hideaki Oikawa*.

Reconstitution of Biosynthetic Machinery for Indole-Diterpene Paxilline inAspergillus oryzae.J. Am. Chem. Soc.135 (4), 1260–63, 2013. DOI: 10.1021/ja3116636

66.Xiaodong Ding, Tadashi Matsumoto, Patrizia Gena,Chengwei Liu, Marialuisa Pellegrini-Calace, Shihua Zhong, Xiaoli Sun, Yanming Zhu, Maki Katsuhara, Ikuko Iwasaki, Yoshichika Kitagawa, Giuseppe Calamita*. Water and CO₂permeability of SsAqpZ, the cyanobacterium Synechococcus sp. PCC7942 aquaporin.Biol. Cell.105 (3), 118-128, 2013. DOI: 10.1111/boc.201200057

67.Motoyoshi Noike,Chengwei Liu, Yusuke Ono, Yoshimitsu Hamano, Tomonobu Toyomasu, Takeshi Sassa, Nobuo Kato, Tohru Dairi*. An Enzyme Catalyzing O-Prenylation of the Glucose Moiety of Fusicoccin A, a Diterpene Glucoside Produced by the FungusPhomopsis amygdali.ChemBioChem.13 (4), 566-73, 2012. DOI: 10.1002/cbic.201100725.

68.Yoshichika Kitagawa*,Chengwei Liu, Xiaodong Ding*.

The influence of natural mineral water on aquaporin water permeability and human natural killer cell activity.Biochem. Biophys. Res. Commun.409 (1), 40-5, 2011. DOI: 10.1016/j.bbrc.2011.04.102

69.劉成偉,松本直，岩崎郁子，北川良親*.

アクアポリンの水透過性と植物のストレス耐性に対する日田天領水の作用.Food Style.13 (1), 92-97, 2009.

70.Tadashi Matsumoto, Hong-Li Lian, Wei-Ai Su, Daisuke Tanaka,Chengwei Liu, Ikuko Iwasaki, Yoshichika Kitagawa*.

Role of the aquaporin PIP1 subfamily in the chilling tolerance of rice.Plant. Cell. Physiol.50 (2), 216-29, 2009. DOI: 10.1093/pcp/pcn190.