劉玉勝，博士，教授，博士生導師
博士畢業于中科大，随後在中科院從事博士後研究，2022年加入伟德官网下app官方网站，主要研究領域為“RNA轉錄後調控：Poly(A)尾巴和可變剪切的動态變化、功能和調控機制”，以第一或通訊作者在Nature Structural & Molecular Biology (2篇)，Nature Communications (2篇)，Nature Protocols，Science China-Life Sciences, iScience 等期刊上發表SCI 論文和著作10篇，授權國家專利2項并轉化1項。
研究方向
開發新的多維度的單細胞高通量測序方法；探索哺乳動物母源-合子轉變過程中表觀動态變化規律、母源物質降解模式、合子基因激活機制等；拓展poly(A)尾巴的調控功能以及在mRNA基因治療及mRNA疫苗中的應用。
代表性成果（# first authors; * corresponding authors）
1. Yusheng Liu#*, Wenrong Tao#, Shuang Wu#, Yiwei Zhang, Hu Nie, Zhenzhen Hou, Jingye Zhang, Zhen Yang, Zi-Jiang Chen, Jiaqiang Wang*, Falong Lu*, Keliang Wu*. Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes. Nature Communications, 2024, 15(1):5550.
2. Jiaqiang Wang*, Yiwei Zhang, Jiaze Gao, Guihai Feng, Chao Liu, Xueke Li, Pengcheng Li, Zhonghua Liu, Falong Lu, Leyun Wang*, Wei Li*, Qi Zhou*, Yusheng Liu*. Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos. Nature Structural & Molecular Biology, 2024, 31(9):1341-1354.
3. Yusheng Liu#, Keliang Wu#, Fanghong Shao#, Hu Nie, Jingye Zhang, Cheng Li, Zhenzhen Hou, Jiaqiang Wang*, Bing Zhou*, Han Zhao*, Falong Lu*. Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition. Nature Structural & Molecular Biology, 2023, 30(2): 200-215.
4. Shuang Wu, Yiwei Zhang, Lan Yao, Jiaqiang Wang*, Falong Lu*, and Yusheng Liu*. m(6)A-modified RNA possess distinct poly(A) tails. J Genet Genomics. 2022, 50(3):208-211.
5. Yusheng Liu#*, Hu Nie#, Yiwei Zhang#, Falong Lu*, Jiaqiang Wang*, Comprehensive analysis of mRNA poly(A) tails by PAIso-seq2, Science China-Life Sciences, 2022, 66(1): 187-190.
6. Yusheng Liu*, Yiwei Zhang, Jiaqiang Wang*, Falong Lu*. Transcriptome-wide measurement of poly(A) tail length and composition at sub-nanogram total RNA sensitivity by PAIso-seq. Nature Protocols, 2022, 17, 1980-2007.
7. Yusheng Liu, Hu Nie, Hongxiang Liu, Falong Lu*. Dynamic RNA 3' Uridylation and Guanylation during Mitosis. iScience, 2020. 23(8): p. 101402.
8. Yusheng Liu#, Hu Nie#, Hongxiang Liu, Falong Lu*. Poly(A) inclusive RNA isoform sequencing (PAIso-seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails. Nature Communications, 2019. 10(1): p. 5292.
9. Yusheng Liu#, Xukun Lu#, Junchao Shi, Xingjiang Yu, Xiaoxin Zhang, Kai Zhu, Zhaohong Yi, Enkui Duan, Lei Li*. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis. Journal of Molecular Cell Biology, 2016, 8(4): 366-368.
10. Yusheng Liu*, Falong Lu*, Jiaqiang Wang*. Sequencing of Transcriptome-Wide Poly(A) Tails by PAIso-seq. Deadenylation: Methods and Protocols. Methods in Molecular Biology, 2024:2723:215-232(Book chapter).
科研項目
(1) 國自然，面上項目，在研，主持。
(2) 國自然，青年基金，在研，主持。
(3) 省基金，優秀青年，在研，主持。
(4) 中國博士後基金，特别資助，結題，主持。
(5) 中國博士後基金，面上項目，結題，主持。
專利
(1) 陸發隆; 劉玉勝, 一種待測樣品中具有poly(A)尾巴的RNA的測序文庫的構建方法, 2019-09-05, 中國, ZL201910837492.2 (已轉化)
(2) 劉玉勝; 陸發隆, poly(A)尾巴非A修飾在促進mRNA翻譯中的應用, 2024-1-23, 中國, ZL202210410067.7
招聘信息
1. 本實驗室常年招收博士後。
2. 非常歡迎對生命科學或生物信息學有強烈好奇心且樂于動手的大一新生來實驗室實習。
聯系方式
E-mail：lys@nefu.edu.cn
電話：19969729912
地址：黑龍江省哈爾濱香坊區和興路26号，伟德官网下app官方网站（新逸夫教學樓）
